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The active substance (INN), Abacavir (Abacavir)
The use of Abacavir: HIV infection (combination therapy).
Contra Abacavir: Hypersensitivity.
Restrictions apply: Liver disease, early infancy (up to 3 months) breastfeeding.
Side effects: delayed-type hypersensitivity reactions (sometimes - life-threatening): fever, malaise, fatigue, gastrointestinal disorders (dry mouth, nausea, vomiting, diarrhea, abdominal pain), coughing, shortness of breath, lower blood pressure, swelling and pain in joints , headache, weakness, sleep disturbances, loss of appetite, hepatomegaly, hepatic steatosis, pancreatitis, lactic acidosis, rash.
Interaction: Possible competition for alcohol dehydrogenase with drugs metabolized by its participation (retinoids).
Dosing and Administration: inside, regardless of the meal, in a strictly defined hours, adults and adolescents over 12 years - and 1 table. (300 mg) or 15 ml (at the inability or the inability to swallow tablets) 2 times a day for children from 3 months to 12 years - 8 mg / kg body weight 2 times a day, but not more than 600 mg.
Precautions: Monotherapy is not allowed. Prescribe the drug can only be a specialist with experience treating HIV infection. Before beginning active antiretroviral therapy through a complete clinical and laboratory examination of the patient, including determined by the level of viral load in plasma and CD4 T lymphocytes. In the course of treatment shows a regular (every 3-6 months) assessment of the level of replication process in viral load in plasma (the definition of bDNK and RT-PCR) and the level of CD4 cells. In the presence of clinical symptoms of HIV infection should start therapy without regard to the number of CD4 cells and viral load in plasma. The appearance of any signs of hypersensitivity reactions (commonly found in the first 6 weeks of treatment) because of their potential danger to life requires stopping (and later drug use is unacceptable). The patient should be warned that the treatment does not reduce the risk of transmitting HIV to others.
